The original Mother of Runes appeared in Urza's Legacy, in 1999.
The original art was by Scott M. Fischer.
Commander Legends: Battle for Baldur's Gate
The List
Secret Lair Drop
Secret Lair Drop
Secret Lair Drop
Secret Lair Drop
Commander Anthology
Eternal Masters
Duel Decks: Elspeth vs. Kiora
Friday Night Magic 2004
Urza's Legacy